delight: girl with parakeet (serious consultation)
primum non nocere sans documentum ([personal profile] delight) wrote2016-02-18 09:40 pm

(no subject)

Dear readers, people who clicked on my name on network, etc,

Today my neurologist decided she really wanted to be able to make triptans accessible to me because of concerns about my abortive therapy availability. This means she has proposed switching from escitalopram, the 6th in a series of antidepressants I've taken for a long time and failed, to effexor, which ... I only trialed for three weeks and then got switched and was about sixteen at the time.

Because it's not an SSRI it's apparently triptan-friendly.

I'm confident I'd stay on Wellbutrin because I need that for executive functioning things too, the escitalopram is largely there just to counter the anxiety that the Wellbutrin makes worse, but --

But, I know quite a few people who read my DW at times take venlafaxine, so please tell me what you think of it, what the onset period was like, how it works in comparison to other things, &c? Much appreciated in advance!
recessional: a photo image of feet in sparkly red shoes (Default)

[personal profile] recessional 2016-02-19 02:52 am (UTC)(link)
- works in comparison to other things: like all these drugs, honestly nobody else's experience is going to be very helpful, because who the hell knows? Escitalopram was my mother's magic drug but only moderately worked for me. If you can't make concrete guesses on a 50%-shared-genetics basis, anything else is pretty iffy.

- onset period was actually better, for me, than any of the other ones were. On the flipside withdrawal symptoms kick in VERY fast if I am even too many hours late with a dose, and are gnarly. For me.

- It's worked better than other things, but on the other hand that's kind of damning with faint praise? It's followed the same general pattern everything else has, which is a marked improvement for about half a year and then a slow slide back to Really Bad, which is where I'm kind of at now. But the fact that that's happened with four different antidepressants now is, I think, kind of indicative: this is apparently a trick my brain pulls, and will not necessarily have any bearing on what it does for you?
recessional: four capsules, all with winking or smiling faces (personal; HAPPY PILLS)

[personal profile] recessional 2016-02-19 03:27 am (UTC)(link)
Yeah no the closest I know of to that is that for the vast majority of people it is a shitty one to taper off of later. But I even know someone who had no discontinuiation problems with it even though she did it in the Unapproved Way, so.

Its weird quirk is that it functions the same as an ssri at lower doses, then at medium/standard doses inhibits reuptake of both serotonin and norepinephrine, and then at high doses adds dopamine.

It's possible that a higher dose is the answer for me, but I'm at the point where my GP isn't comfortable going higher and I'm not interested in fucking around with meds anymore without having a psychiatrist monitoring it so I'm waiting for my referral to go through. Sigh.

Also it's one of those pain in the ass things where it is shown by studies to both significantly decrease migraines . . . in some people, and trigger more of them in others. Which, like: in the people that it TREATS migraines in, it does as well as a lot of the actual designated treatments! But I'm concerned that it may be increasing mine. *headdesk*
Edited (I will stop editing this now I swear.) 2016-02-19 03:29 (UTC)
weaver: (Default)

[personal profile] weaver 2016-02-19 12:40 pm (UTC)(link)
oh hello, I can help! I spent about a year, maaaybe two? or three? on Efexor, and I did not have any major problems. It really does let you know in no uncertain terms if you miss a dose, but I also came off it by just ... kinda forgetting more days than I didn't, and then deciding I didn't want it any more, and I didn't have any significant side effects for that, either. I can't really compare it to much - I think I tried Lovan and ... Cymbalta maybe? is that one? but nothing had any effect until Efexor.

I don't know that it did a lot with my executive functioning; I was then and am still absolutely balls at doing anything until it becomes so urgent I have no choice, etc etc. But that also wasn't a thing I even knew wasn't normal back then, and wasn't on my medical radar at all.

I hope it works out well for you!
kalmialatifolia: (0; gave my body to science&religion)

[personal profile] kalmialatifolia 2016-02-19 03:44 pm (UTC)(link)
okay, cool, i took effexor for ~4 years (alongside seroquel). i was prescribed it during my last hospitalization, at the point where i was suffering psychosis and profound anhedonia. it worked.

onset side effects were non-existent for me, which was a first. i actually never experienced any side effects whatsoever OTHER than the worsening of my migraines and the worsening of my menorrhagia, which WOULDN'T have occurred if i hadn't gone off birth control, so.

it did not cause me the things that a variety of others (incl. wellbutrin, which, yeah, ANXIETY) did, such as urine retention or tachycardia or worsening crazy. it DID make my migraines worse, but, again, like ~recessional said, it can also make them better! being able to take triptans was a plus. it made my PTSD liveable, at any rate. it also ensured that i had more energy. it made me slightly twitchy, which went away after i stopped taking it.

the flipside is that, yeah, like ~recessional said, it has a half-life of 12 hours and some of the most unpleasant withdrawal symptoms i've ever experienced. they're not dangerously bad, just painful--shocks, nausea, blurred vision, dizziness, hot flashes, etc. if nothing else it reminds you to take it...

i stopped taking it because it was...working, and i assumed i no longer needed antidepressants, and, again, i had nothing to counteract the menorrhagia. once i DID stop taking it, i tapered slowly by 1/4 doses and had no withdrawal symptoms.
panda: drawing of a panda sitting in a tea cup which has fallen over on its side (Default)

[personal profile] panda 2016-02-21 02:36 pm (UTC)(link)
I was on effexor xr for several years, several years ago, so my memory is fuzzy but the part I remember clearly is the withdrawal symptoms. From everyone I've talked to, that's the big common side effect many people get. If I missed it for even one day I would start getting them- dizziness, hot/cold flashes, nausea, shocks, feeling like I was going out of my mind... I also remember it fucking with my appetite- I wouldn't feel hungry so I would have to force myself to eat.

It did help my migraines but it didn't help my mood enough, and at the time I was very bad at getting my refills on time, so going through the withdrawal for a couple days most months was ultimately not worth it, even though it was probably the best thing I had ever found for my migraines. If you're good about taking your meds regularly/getting refills in a timely fashion, there's no reason it should be a problem for you though. And good luck, I hope you are one of the people that it helps you with your migraines too.